Liu Ping, Liang Sun, Wang Ben-Jie, Guo Rui-Chen
Institute of Clinical Pharmacology, Qilu Hospital of Shandong University, Jinan 250012, China.
Eur J Drug Metab Pharmacokinet. 2009 Jul-Sep;34(3-4):193-200. doi: 10.1007/BF03191173.
The pharmacokinetics of Tramadol and Promethazine after a single dose of 40, 80 and 120 mg intramuscular injecting CTHI was evaluated in healthy volunteers. Physical exam, vital signs, clinical laboratory tests and electrocardiogram measurements were monitored to assess the safety and tolerance of the drug. The plasma levels of Tramadol and Promethazine in serial samples were measured by a validated HPLC-MS method. No subject showed any drug-related clinically significant changes on physical examination, vital signs or laboratory tests.
在健康志愿者中评估了单次肌肉注射40、80和120毫克复方噻吩嘧啶后曲马多和异丙嗪的药代动力学。监测体格检查、生命体征、临床实验室检查和心电图测量，以评估药物的安全性和耐受性。通过经验证的高效液相色谱-质谱法测量系列样本中曲马多和异丙嗪的血浆水平。在体格检查、生命体征或实验室检查中，没有受试者出现任何与药物相关的具有临床意义的变化。
