The Ohio State University, Nationwide Children's Hospital, 700 Children's Dr W307, Columbus, OH 4320, USA.
Expert Opin Pharmacother. 2010 Apr;11(5):771-8. doi: 10.1517/14656561003592151.
Cystic fibrosis-related diabetes (CFRD) is a unique type of diabetes. In this article I review the pathophysiology of CFRD to gain insight as to why these patients have clinical features of both type 1 and 2 diabetes (DM). The reader will also learn that, although CFRD is different from type 1 and 2 DM, the development of diabetes-induced complications is similar to other types of DM. These complications can include retinopathy, nephropathy and neuropathy resulting from uncontrolled hyperglycemia; however, hyperglycemia and/or insulin deficiency in people with CFRD may exacerbate underlying CF problems, such as decreased pulmonary function and weight loss.
Review medical therapy of CFRD including the over-riding goal of maintaining blood glucose levels in a range as close to normal as possible. The other important goal for diabetes management is to prevent diabetes complications and to encourage psychological wellbeing of the patient. However, as reviewed in this article, the underlying medical condition of people with CF and the basic metabolic differences caused by the disease often provide challenges in maintaining optimal diabetes control.
The reader will gain an understanding of how CFRD physically affects the patient with CF and the various pharmacologic therapies available for treatment of this type of diabetes. Furthermore they will gain insight into areas where more research is needed.
Cystic fibrosis-related diabetes is unique to CF and thus deserves disease specific medical therapy.
囊性纤维化相关性糖尿病（CFRD）是一种独特的糖尿病类型。在本文中，我回顾了 CFRD 的病理生理学，以深入了解为什么这些患者具有 1 型和 2 型糖尿病（DM）的临床特征。读者还将了解到，尽管 CFRD 与 1 型和 2 型 DM 不同，但糖尿病引起的并发症的发展与其他类型的 DM 相似。这些并发症包括由高血糖引起的视网膜病变、肾病和神经病变；然而，CFRD 患者的高血糖和/或胰岛素缺乏可能会加重潜在的 CF 问题，如肺功能下降和体重减轻。
本综述包括 CFRD 的医学治疗，包括将血糖水平控制在尽可能接近正常范围内的首要目标。糖尿病管理的另一个重要目标是预防糖尿病并发症并鼓励患者的心理健康。然而，如本文所述，CF 患者的潜在医疗状况和由该疾病引起的基本代谢差异常常在维持最佳糖尿病控制方面带来挑战。
读者将了解 CFRD 如何对 CF 患者造成身体影响，以及治疗这种类型糖尿病的各种药物治疗。此外，他们将深入了解需要进一步研究的领域。
囊性纤维化相关性糖尿病是 CF 所特有的，因此值得采用针对疾病的特定医学治疗。
