Departamento de Farmacología, Facultad de Farmacia. University of Santiago de Compostela. E-15782 Spain.
Curr Top Med Chem. 2010;10(5):493-503. doi: 10.2174/156802610791111524.
5-HT(2B) receptors have been reported to play an important role at cardiac, intestinal and central levels, as well as in bone marrow formation and growth. In the last decade, 5-HT(2B) receptors have also gained much attention as new targets in therapeutics, but also as off-targets because their activation along with the inhibition of serotonin transporters plays a significant role in the pathogenesis of 5-HT induced valvulopathy. Taking this into account, the present review focuses on the new therapeutic applications of 5-HT(2B) receptor ligands as well as on the potential concerns.
5-HT（2B）受体在心脏、肠道和中枢神经系统以及骨髓形成和生长中发挥着重要作用。在过去的十年中，5-HT（2B）受体也因其作为治疗靶点而备受关注，但也因其作为非靶点而备受关注，因为它们的激活以及 5-HT 诱导的瓣膜病发病机制中 5-羟色胺转运体的抑制作用发挥了重要作用。考虑到这一点，本综述重点介绍了 5-HT（2B）受体配体的新治疗应用以及潜在的关注点。
