Dept.of Urology, Leiden University Medical Center, Albinusdreef 2, PO Box 9600, 2300 RC, Leiden, The Netherlands.
Curr Pharm Des. 2010;16(11):1291-300. doi: 10.2174/138161210791033987.
Breast and prostate cancer are osteotropic cancers, i.e., carcinomas that have a special predilection to form bone metastases. At postmortem examination, approximately 70% of patients dying of these cancers have evidence of metastatic bone disease. Bone Morphogenetic Proteins (BMPs) were first identified by their ability to induce ectopic bone formation in vivo. Since prostate cancer cells express several BMPs, BMPs have been implicated in the osteoblastic phenotype of bone metastases. In addition to their osteogenic function, BMPs turned out to be multifunctional proteins regulating cell growth, differentiation, migration, and apoptosis in various target cells, including breast and prostate cancer cells. Especially in the last decade, studies have focused on the role of several BMPs in osteotropic cancers. In this review, the role of BMPs, particularly that of BMP7, in breast and prostate cancer will be discussed.
乳腺癌和前列腺癌是亲骨性癌症，即具有特殊倾向形成骨转移的癌。尸检时，约 70%死于这些癌症的患者有骨转移疾病的证据。骨形态发生蛋白（BMPs）最初因其在体内诱导异位骨形成的能力而被识别。由于前列腺癌细胞表达几种 BMPs，因此 BMPs 被认为与骨转移的成骨表型有关。除了成骨功能外，BMPs 还是多功能蛋白，可调节各种靶细胞（包括乳腺癌和前列腺癌细胞）中的细胞生长、分化、迁移和凋亡。特别是在过去十年中，研究集中在几种 BMPs 在亲骨性癌症中的作用。在这篇综述中，将讨论 BMPs，特别是 BMP7 在乳腺癌和前列腺癌中的作用。
