Rao Anoop, Wiley Meg, Iyengar Sridhar, Nadeau Dan, Carnevale Julie
AgaMatrix Inc, Salem, New Hampshire, USA.
J Diabetes Sci Technol. 2010 Jan 1;4(1):145-50. doi: 10.1177/193229681000400118.
Studies have shown that controlling blood glucose can reduce the onset and progression of the long-term microvascular and neuropathic complications associated with the chronic course of diabetes mellitus. Improved glycemic control can be achieved by frequent testing combined with changes in medication, exercise, and diet. Technological advancements have enabled improvements in analytical accuracy of meters, and this paper explores two such parameters to which that accuracy can be attributed.
Four blood glucose monitoring systems (with or without dynamic electrochemistry algorithms, codeless or requiring coding prior to testing) were evaluated and compared with respect to their accuracy.
Altogether, 108 blood glucose values were obtained for each system from 54 study participants and compared with the reference values. The analysis depicted in the International Organization for Standardization table format indicates that the devices with dynamic electrochemistry and the codeless feature had the highest proportion of acceptable results overall (System A, 101/103). Results were significant when compared at the 10% bias level with meters that were codeless and utilized static electrochemistry (p = .017) or systems that had static electrochemistry but needed coding (p = .008).
Analytical performance of these blood glucose meters differed significantly depending on their technologic features. Meters that utilized dynamic electrochemistry and did not require coding were more accurate than meters that used static electrochemistry or required coding.
研究表明,控制血糖可减少与糖尿病慢性病程相关的长期微血管和神经病变并发症的发生及进展。通过频繁检测并结合药物、运动和饮食的调整,可实现更好的血糖控制。技术进步提高了血糖仪的分析准确性,本文探讨了可归因于这种准确性的两个参数。
对四种血糖监测系统(有无动态电化学算法、无需编码或检测前需编码)的准确性进行了评估和比较。
从54名研究参与者那里,每个系统共获得108个血糖值,并与参考值进行比较。以国际标准化组织表格形式呈现的分析表明,具有动态电化学和无需编码功能的设备总体上可接受结果的比例最高(系统A,101/103)。与无需编码且采用静态电化学的血糖仪(p = 0.017)或采用静态电化学但需要编码的系统(p = 0.008)在10%偏差水平下进行比较时,结果具有显著性。
这些血糖仪的分析性能因其技术特性而有显著差异。采用动态电化学且无需编码的血糖仪比采用静态电化学或需要编码的血糖仪更准确。