血小板激活因子（PAF）在全身炎症反应中的信号级联。
The platelet activating factor (PAF) signaling cascade in systemic inflammatory responses.
机构信息
Department of Pediatrics, University of Utah, Salt Lake City, UT 84112, USA.
出版信息
Biochimie. 2010 Jun;92(6):692-7. doi: 10.1016/j.biochi.2010.02.011. Epub 2010 Feb 16.
Abstract
The platelet-activating factor (PAF) signaling cascade evolved as a component of the repertoire of innate host defenses, but is also an effector pathway in inflammatory and thrombotic diseases. This review focuses on the PAF signaling cascade in systemic inflammatory responses and, specifically, explores its activities in experimental and clinical sepsis and anaphylaxis in the context of the basic biochemistry and biology of signaling via this lipid mediator system.
摘要
血小板激活因子 (PAF) 信号级联反应是先天宿主防御机制的组成部分，但也是炎症和血栓性疾病的效应途径。本篇综述重点关注全身炎症反应中的 PAF 信号级联反应，并特别探讨了在该脂质介质系统信号转导的基础生物化学和生物学背景下，其在实验性和临床脓毒症和过敏反应中的作用。
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