Department of Psychology, University of Leuven, Leuven, Belgium.
J Affect Disord. 2010 Oct;126(1-2):174-9. doi: 10.1016/j.jad.2010.01.073. Epub 2010 Feb 18.
Little is known about factors predicting treatment outcome in chronic fatigue syndrome (CFS).
Based on Vercoulen et al.'s (1998) cognitive-behavioral model of perpetuating factors in CFS, the predictive value of the following patient characteristics were examined in a sample of 178 CFS patients who followed a multi-component treatment program: (1) somatic attributions, (2) psychological attributions, (3) sense of control over symptoms, (4) physical activity, (5) functional impairment, (6) somatic focus, and (7) severity of depression.
Only pre-treatment severity of depression was associated with negative treatment outcome defined in terms of post-treatment fatigue and improvement in fatigue.
The study was conducted at a tertiary care centre and did not include a control group or a long-term follow-up.
Level of depression may be the most important factor of the cognitive-behavioral model predicting post-treatment fatigue in CFS. Hence, findings suggest that treatment of CFS should include a focus on severity of depression.
对于慢性疲劳综合征（CFS）的治疗结果预测因素知之甚少。
基于 Vercoulen 等人（1998）的 CFS 持续因素认知行为模型，在接受多组分治疗方案的 178 名 CFS 患者样本中，检查了以下患者特征对治疗结果的预测价值：（1）躯体归因，（2）心理归因，（3）对症状的控制感，（4）身体活动，（5）功能障碍，（6）躯体焦点，和（7）抑郁严重程度。
只有治疗前的抑郁严重程度与以治疗后疲劳和疲劳改善来定义的消极治疗结果相关。
该研究在三级护理中心进行，未包括对照组或长期随访。
抑郁程度可能是预测 CFS 治疗后疲劳的认知行为模型中最重要的因素。因此，研究结果表明，CFS 的治疗应侧重于抑郁的严重程度。
