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对华法林治疗患者局部使用咪康唑抗真菌口腔凝胶:一则警示

Topical use of miconazole antifungal oral gel on warfarinized patients: a word of caution.

作者信息

Ezsiás A, Wojnarowska F, Juniper R

机构信息

Department of Oral and Maxillofacial Surgery, John Radcliffe Hospital, Oxford.

出版信息

Dent Update. 1997 Dec;24(10):421-2.

PMID:9534418
Abstract

Oral candidosis is common, particularly in elderly patients who wear dentures. Many of these patients also have systemic diseases, including conditions for which they have to take oral anticoagulants, most commonly warfarin. Although the effect of parenterally administered miconazole on anticoagulant control is well known, the fact that small amounts of topically applied miconazole oral gel can have a similar effect is poorly recognized.

摘要

口腔念珠菌病很常见,尤其是在佩戴假牙的老年患者中。这些患者中的许多人还患有全身性疾病,包括他们必须服用口服抗凝剂的疾病,最常见的是华法林。虽然胃肠外给予咪康唑对抗凝控制的影响是众所周知的,但局部应用少量咪康唑口腔凝胶也可能有类似影响这一事实却鲜为人知。

相似文献

1
Topical use of miconazole antifungal oral gel on warfarinized patients: a word of caution.对华法林治疗患者局部使用咪康唑抗真菌口腔凝胶:一则警示
Dent Update. 1997 Dec;24(10):421-2.
2
Miconazole oral gel potentiates warfarin anticoagulant activity.咪康唑口腔凝胶增强华法林的抗凝活性。
Thromb Haemost. 2000 May;83(5):794-5.
3
Interaction between miconazole oral gel (Daktarin) and warfarin.咪康唑口腔凝胶(达克宁)与华法林之间的相互作用。
N Z Med J. 1996 Sep 13;109(1029):346.
4
Miconazole and nystatin used as topical antifungal drugs interact equally strongly with warfarin.咪康唑和制霉菌素作为局部抗真菌药物与华法林同样强烈地相互作用。
J Clin Pharm Ther. 2012 Feb;37(1):45-8. doi: 10.1111/j.1365-2710.2011.01246.x. Epub 2011 Feb 17.
5
[Interaction between warfarin and oral miconazole gel].[华法林与口服咪康唑凝胶之间的相互作用]
Ugeskr Laeger. 2000 Oct 9;162(41):5511.
6
Miconazole oral gel and drug interactions.咪康唑口腔凝胶与药物相互作用。
Br Dent J. 2004 May 8;196(9):529-31. doi: 10.1038/sj.bdj.4811224.
7
[Near asphyxiation of a neonate due to miconazole oral gel].[咪康唑口腔凝胶致新生儿近乎窒息]
Ned Tijdschr Geneeskd. 2004 Aug 7;148(32):1598-600.
8
Miconazole buccal gel and risk for systemic bleeding: how certain topical formula can interfere with anticoagulants.咪康唑口腔凝胶与全身出血风险:某些局部用药配方如何干扰抗凝剂。
Acta Clin Belg. 2015 Apr;70(2):121-3. doi: 10.1179/2295333714Y.0000000089. Epub 2014 Oct 21.
9
Comparison of the efficacy and safety of miconazole 50-mg mucoadhesive buccal tablets with miconazole 500-mg gel in the treatment of oropharyngeal candidiasis: a prospective, randomized, single-blind, multicenter, comparative, phase III trial in patients treated with radiotherapy for head and neck cancer.50毫克咪康唑粘膜粘附口腔片与500毫克咪康唑凝胶治疗口咽念珠菌病的疗效和安全性比较:一项针对头颈部癌放疗患者的前瞻性、随机、单盲、多中心、对照、III期试验。
Cancer. 2008 Jan 1;112(1):204-11. doi: 10.1002/cncr.23152.
10
Miconazole oral gel enhances acenocoumarol anticoagulant activity: a report of three cases.咪康唑口腔凝胶增强醋硝香豆素抗凝活性:三例报告
Ann Pharmacother. 1999 Feb;33(2):175-7. doi: 10.1345/aph.18011.

引用本文的文献

1
Morbidity and mortality associated with the interaction of miconazole oral gel and warfarin.咪康唑口腔凝胶与华法林相互作用相关的发病率和死亡率。
Br Dent J. 2018 Jul 27;225(2):129-132. doi: 10.1038/sj.bdj.2018.534.
2
Drug interaction presenting as acute abdomen.表现为急腹症的药物相互作用。
World J Gastrointest Pharmacol Ther. 2010 Feb 6;1(1):40-2. doi: 10.4292/wjgpt.v1.i1.40.
3
Drug and dietary interactions of warfarin and novel oral anticoagulants: an update.华法林和新型口服抗凝剂的药物和饮食相互作用:最新进展。
J Thromb Thrombolysis. 2011 Apr;31(3):326-43. doi: 10.1007/s11239-011-0561-1.