Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, Patras, Greece.
Eur Cytokine Netw. 2009 Dec;20(4):180-90. doi: 10.1684/ecn.2009.0172.
Pleiotrophin (PTN) is a heparin-binding growth factor with diverse biological activities, the most studied of these being those related to the nervous system, tumor growth and angiogenesis. Although interest in the involvement of PTN in tumor growth is increasing, many questions remain unanswered, particularly concerning the receptors and the signaling pathways involved. In this review, we briefly introduce PTN, and summarize data on its involvement in tumor growth and angiogenesis, and on what is known to date concerning the receptors and pathways involved.
多效蛋白（PTN）是一种肝素结合生长因子，具有多种生物学活性，其中研究最多的是与神经系统、肿瘤生长和血管生成相关的活性。尽管人们对 PTN 参与肿瘤生长的兴趣日益增加，但仍有许多问题尚未得到解答，特别是涉及到相关的受体和信号通路。在这篇综述中，我们简要介绍了 PTN，并总结了其在肿瘤生长和血管生成中的作用，以及目前已知的涉及的受体和信号通路的相关数据。
