Department of Medical and Morphological Research, Anatomy Section, University of Udine Medical School, Udine, Italy.
Eur Cytokine Netw. 2009 Dec;20(4):197-206. doi: 10.1684/ecn.2009.0167.
Mast cells (MCs) are tissue leukocytes that are distributed throughout the major organs of the body. They are an important local source of preformed and newly synthesized angiogenic molecules. MCs have been linked both to inflammatory and tumor angiogenesis. Indeed, numerous solid tumors and hematological malignancies present MC-rich infiltrates, which are believed to contribute to the formation of a new vascular supply. In addition, angiogenesis and MC density have been shown to increase simultaneously with the pathological progression in many of such tumors. This review will focus on the angiogenic potential of MCs in human solid and hematological tumors.
肥大细胞（MCs）是分布在全身主要器官的组织白细胞。它们是预先形成和新合成的血管生成分子的重要局部来源。MCs 与炎症和肿瘤血管生成都有关。事实上，许多实体瘤和血液恶性肿瘤存在富含 MC 的浸润，据信这有助于形成新的血管供应。此外，在许多此类肿瘤中，血管生成和 MC 密度都随着病理进展而同时增加。这篇综述将重点介绍 MC 在人类实体瘤和血液恶性肿瘤中的血管生成潜力。
