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mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis.
Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3281-2. doi: 10.1073/pnas.1000323107. Epub 2010 Feb 18.
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Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis.
Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3441-6. doi: 10.1073/pnas.0914798107. Epub 2010 Feb 1.
3
Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase.
Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16184-9. doi: 10.1073/pnas.1213343109. Epub 2012 Aug 27.
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Long Noncoding RNA lncSHGL Recruits hnRNPA1 to Suppress Hepatic Gluconeogenesis and Lipogenesis.
Diabetes. 2018 Apr;67(4):581-593. doi: 10.2337/db17-0799. Epub 2018 Jan 30.
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E4BP4 is an insulin-induced stabilizer of nuclear SREBP-1c and promotes SREBP-1c-mediated lipogenesis.
J Lipid Res. 2016 Jul;57(7):1219-30. doi: 10.1194/jlr.M067181. Epub 2016 Jun 1.
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mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC).
PLoS One. 2015 Jun 4;10(6):e0126240. doi: 10.1371/journal.pone.0126240. eCollection 2015.
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Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c.
Cell Metab. 2012 May 2;15(5):725-38. doi: 10.1016/j.cmet.2012.03.015. Epub 2012 Apr 19.

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Dietary Restriction and Lipid Metabolism: Unveiling Pathways to Extended Healthspan.
Nutrients. 2024 Dec 23;16(24):4424. doi: 10.3390/nu16244424.
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Regulation of Liver Glucose and Lipid Metabolism by Transcriptional Factors and Coactivators.
Life (Basel). 2023 Feb 13;13(2):515. doi: 10.3390/life13020515.
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An integrative approach to assessing effects of a short-term Western diet on gene expression in rat liver.
Front Endocrinol (Lausanne). 2022 Oct 26;13:1032293. doi: 10.3389/fendo.2022.1032293. eCollection 2022.
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Modulation of Breast Cancer Cell FASN Expression by Obesity-Related Systemic Factors.
Breast Cancer (Auckl). 2022 Aug 22;16:11782234221111374. doi: 10.1177/11782234221111374. eCollection 2022.
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Estrogen Mediates an Atherosclerotic-Protective Action Estrogen Receptor Alpha/SREBP-1 Signaling.
Front Cardiovasc Med. 2022 Jul 5;9:895916. doi: 10.3389/fcvm.2022.895916. eCollection 2022.
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Trends in insulin resistance: insights into mechanisms and therapeutic strategy.
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Autophagy and the Lysosomal System in Cancer.
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本文引用的文献

1
Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis.
Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3441-6. doi: 10.1073/pnas.0914798107. Epub 2010 Feb 1.
2
An emerging role of mTOR in lipid biosynthesis.
Curr Biol. 2009 Dec 1;19(22):R1046-52. doi: 10.1016/j.cub.2009.09.058.
3
mTOR signaling at a glance.
J Cell Sci. 2009 Oct 15;122(Pt 20):3589-94. doi: 10.1242/jcs.051011.
4
GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice.
J Clin Invest. 2009 May;119(5):1201-15. doi: 10.1172/JCI37007. Epub 2009 Apr 13.
7
SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.
Cell Metab. 2008 Sep;8(3):224-36. doi: 10.1016/j.cmet.2008.07.007.
8
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.
Science. 2008 Jun 13;320(5882):1496-501. doi: 10.1126/science.1157535. Epub 2008 May 22.
9
Role of the PI3-kinase/mTor pathway in the regulation of the stearoyl CoA desaturase (SCD1) gene expression by insulin in liver.
J Cell Commun Signal. 2007 Sep;1(2):113-25. doi: 10.1007/s12079-007-0011-1. Epub 2007 Oct 6.
10
The FoxO code.
Oncogene. 2008 Apr 7;27(16):2276-88. doi: 10.1038/onc.2008.21.

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