自噬作用和溶酶体系统在癌症中的作用。
Autophagy and the Lysosomal System in Cancer.
机构信息
Autophagy Inflammation and Metabolism Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
出版信息
Cells. 2021 Oct 14;10(10):2752. doi: 10.3390/cells10102752.
Autophagy and the lysosomal system, together referred to as the autophagolysosomal system, is a cellular quality control network which maintains cellular health and homeostasis by removing cellular waste including protein aggregates, damaged organelles, and invading pathogens. As such, the autophagolysosomal system has roles in a variety of pathophysiological disorders, including cancer, neurological disorders, immune- and inflammation-related diseases, and metabolic alterations, among others. The autophagolysosomal system is controlled by TFEB, a master transcriptional regulator driving the expression of multiple genes, including autophagoly sosomal components. Importantly, Reactive Oxygen Species (ROS) production and control are key aspects of the physiopathological roles of the autophagolysosomal system, and may hold a key for synergistic therapeutic interventions. In this study, we reviewed our current knowledge on the biology and physiopathology of the autophagolysosomal system, and its potential for therapeutic intervention in cancer.
自噬和溶酶体系统，合称为自噬溶酶体系统，是一种细胞质量控制系统，通过清除包括蛋白质聚集体、受损细胞器和入侵病原体在内的细胞废物来维持细胞健康和内稳态。因此，自噬溶酶体系统在多种病理生理紊乱中发挥作用，包括癌症、神经紊乱、免疫和炎症相关疾病以及代谢改变等。自噬溶酶体系统受 TFEB 控制，TFEB 是一种主转录调控因子，可驱动多种基因的表达，包括自噬溶酶体成分。重要的是，活性氧（ROS）的产生和控制是自噬溶酶体系统生理病理作用的关键方面，并且可能是协同治疗干预的关键。在本研究中，我们回顾了自噬溶酶体系统的生物学和生理病理学及其在癌症治疗中的潜在应用的现有知识。
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