Erwig L-P, Savage C O S
School of Medicine, Institute of Medical Sciences, Foresterhill, University of Aberdeen, UK.
Neth J Med. 2010 Feb;68(2):62-7.
Substantial progress has been made over the last two decades in our understanding of the immunopathogenesis of antineutrophil cytoplasmic antibodies (ANCA) associated vasculitides. Compelling evidence from in vitro studies and experimental models in conjunction with clinical trials has confirmed that ANCA directly contribute to the evolution and progression of the disease process. Continuous development in our understanding of the mechanisms that drive the disease may ultimately allow us to tailor the multitude of novel therapies, which are rapidly becoming available, to the requirements of individual patients. In this review we endeavour to provide a brief overview of the recent advances in ANCA-associated vasculitides and outline basic principles for diagnosis and treatment of these complex multisystem diseases.
在过去二十年里，我们对抗中性粒细胞胞浆抗体（ANCA）相关血管炎的免疫发病机制的理解取得了重大进展。来自体外研究、实验模型以及临床试验的确凿证据证实，ANCA直接促成了疾病进程的演变和进展。我们对驱动该疾病机制的理解不断深入，最终可能使我们能够根据个体患者的需求，定制众多迅速问世的新型疗法。在这篇综述中，我们力图简要概述ANCA相关血管炎的最新进展，并概述这些复杂多系统疾病的诊断和治疗基本原则。
