Birck Rainer, Kaelsch Isabelle, Schnuelle Peter, Flores-Suárez Luis Felipe, Nowack Rainer
Fifth Department of Medicine, University Hospital Mannheim, Germany.
J Clin Rheumatol. 2009 Sep;15(6):289-91. doi: 10.1097/RHU.0b013e3181b55fe4.
Whether autoimmune or rheumatic disease may be precipitated after vaccination is controversially discussed among experts. Here we describe 4 cases of new onset or relapsing antineutrophil cytoplasmic antibodies associated vasculitis occurring in timely association with influenza vaccination. In the literature different subtypes of vasculitis have been repeatedly reported after influenza vaccination. Several trials in patients with preexisting auto-immune disease failed to indicate an increased risk for disease recurrence after influenza vaccination but these investigations might be underpowered to detect this very rare but relevant side effect. Although our report does not prove a causal association between vaccination and vasculitis, it seems possible that in rare cases vaccination might induce vasculitic disease.
接种疫苗后是否会引发自身免疫性疾病或风湿性疾病在专家中存在争议。在此，我们描述了4例与流感疫苗接种及时相关的新发或复发性抗中性粒细胞胞浆抗体相关性血管炎病例。文献中已多次报道流感疫苗接种后出现不同亚型的血管炎。几项针对已有自身免疫性疾病患者的试验未能表明流感疫苗接种后疾病复发风险增加，但这些研究可能因样本量不足而无法检测到这种非常罕见但相关的副作用。虽然我们的报告并未证明疫苗接种与血管炎之间存在因果关系，但在罕见情况下，疫苗接种可能诱发血管炎性疾病似乎是有可能的。
