Brothman A R, Wilkins P C, Sales E W, Somers K D
Department of Pediatrics, Eastern Virginia Medical School, Norfolk 23501.
J Urol. 1991 May;145(5):1088-91. doi: 10.1016/s0022-5347(17)38540-3.
Limitation in the number of human prostatic cell lines has created a gap in knowledge regarding the in-vivo progression of this common cancer. The recently isolated primary prostatic carcinoma cell line, PPC-1, has been shown to be tumorigenic in athymic nude mice. These cells are now shown to form metastases to secondary sites in 10 of 12 animals in this initial study. Metastases were localized to lung and lymph nodes, and the tumor histology closely resembled that of the undifferentiated, rapidly dividing primary tumors. This is the first report describing the metastatic properties of a primary prostatic cancer cell line. PPC-1 cells are therefore likely to represent a good model system for the study of human prostate cancer progression.
人类前列腺癌细胞系数量有限，这使得我们对这种常见癌症的体内进展情况的了解存在空白。最近分离出的原发性前列腺癌细胞系PPC - 1已被证明在无胸腺裸鼠中具有致瘤性。在这项初步研究中，现在显示这些细胞在12只动物中的10只中形成了转移至次要部位的情况。转移灶定位于肺和淋巴结，肿瘤组织学与未分化、快速分裂的原发性肿瘤非常相似。这是第一份描述原发性前列腺癌细胞系转移特性的报告。因此，PPC - 1细胞可能是研究人类前列腺癌进展的良好模型系统。
