Ware J L, Lieberman A P, Webb K S, Vollmer R T
Exp Cell Biol. 1985;53(3):163-9. doi: 10.1159/000163308.
Three related human prostate carcinoma cell lines, PC-3, 1-LN-PC-3-1A (1-LN), and 1-LN-PC-3-1A clone 4 (clone 4) were compared in terms of relative metastatic capacity in adult and young male nude mice. Only 1-LN produced lung metastases after intravenous injection into both 6- to 8-week-old and 4-week-old nude mice, as well as in mice injected intraperitoneally. The extent of the phenotypic diversity exhibited by these human prostate tumor lines was influenced by inherent dissemination ability, age of the host, and route of injection. These lines provide a useful system for the analysis of the biology of human tumor metastasis in nude mice.
对三种相关的人前列腺癌细胞系PC-3、1-LN-PC-3-1A（1-LN）和1-LN-PC-3-1A克隆4（克隆4）在成年和幼年雄性裸鼠中的相对转移能力进行了比较。仅1-LN在静脉注射到6至8周龄和4周龄的裸鼠以及腹腔注射的小鼠中产生了肺转移。这些人前列腺肿瘤细胞系表现出的表型多样性程度受内在播散能力、宿主年龄和注射途径的影响。这些细胞系为分析裸鼠中人肿瘤转移的生物学特性提供了一个有用的系统。
