水通道蛋白 1 不仅是一个水通道：它通过 Lin7/β-连环蛋白促进细胞迁移。
AQP1 is not only a water channel: It contributes to cell migration through Lin7/beta-catenin.
机构信息
Department of Biomolecular Science and Biotechnology, University of Milan, Milan, Italy.
出版信息
Cell Adh Migr. 2010 Apr-Jun;4(2):204-6. doi: 10.4161/cam.4.2.10949. Epub 2010 Apr 15.
Abstract
AQPs are water channel proteins. In particular, AQP1 was demonstrated to be involved in cell migration. According to the model proposed by Verkman and collaborators, AQP drives water influx, facilitating lamellipodia extension and cell migration. Investigating the possible connection between AQP1 and cytoskeleton, our group showed that such a water channel through Lin7/beta-catenin affects the organization of the cytoskeleton and proposed a model. All together, these data appear particularly intriguing since the use of AQP1 as target might be useful to modulate angiogenesis/vasculogenic mimicry.
摘要
水通道蛋白（AQPs）是水通道蛋白。特别是，AQP1 被证明参与细胞迁移。根据 Verkman 及其同事提出的模型，AQP 驱动水流入，促进片状伪足延伸和细胞迁移。在研究 AQP1 和细胞骨架之间可能的联系时，我们的小组表明，这种通过 Lin7/β-连环蛋白的水通道会影响细胞骨架的组织，并提出了一个模型。总的来说，这些数据非常有趣，因为将 AQP1 作为靶点可能有助于调节血管生成/血管生成拟态。
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