Keener J P
Department of Mathematics, University of Utah, Salt Lake City 84112.
J Theor Biol. 1991 Jan 7;148(1):49-82. doi: 10.1016/s0022-5193(05)80465-5.
A modified cable theory for a bi-domain model of myocardium that incorporates the effect of gap junctions as discrete objects coupling cardiac cells is derived. The theory is shown to be in agreement with a number of experiments that cannot be explained using standard continuous cable theory, and resolves some apparent contradictions on failure of propagation in two-dimensional anisotropic tissue. In addition, some as yet untested predictions of the theory are mentioned.
