Department of Pediatrics, RWTH Aachen University, 52074 Aachen, Germany.
Gastroenterol Res Pract. 2009;2009:579501. doi: 10.1155/2009/579501. Epub 2010 Feb 11.
The pathophysiological mechanisms for ileocecal intussusception in children with adenovirus infection are not well characterized. Here we demonstrate coincidence of adenovirus infection and inflammatory neuropathy of myenteric plexus in two children with ileocecal intussusception. Inflammatory neuropathy, an unspecific morphological feature which is found in peristalsis disorders, was morphologically characterized by the influx of CD3 positive lymphocytes in nervous plexus. To our knowledge, this is the first report suggesting peristalsis disorders from inflammatory neuropathy as additional mechanism in the pathophysiological concept of adenovirus-associated ileocecal intussusception.
腺病毒感染致回盲肠套叠的病理生理机制尚不清楚。本研究在 2 例回盲肠套叠患儿中发现腺病毒感染与肌间神经丛炎症性神经病同时存在。炎症性神经病是一种非特异性形态学特征，存在于蠕动障碍中，其形态学特征为 CD3 阳性淋巴细胞浸润神经丛。据我们所知，这是首例提示炎症性神经病导致蠕动障碍的报道，这为腺病毒相关性回盲肠套叠的病理生理概念提供了额外的机制。
