慢性阻塞性肺疾病（COPD）和阻塞性睡眠呼吸暂停（OSA）自然史研究人群队列的建立与试点：PULSAIB研究
Set-up and pilot of a population cohort for the study of the natural history of COPD and OSA: the PULSAIB study.
作者信息
Soriano Joan B, Yáñez Aina, Renom Feliu, de la Peña Mónica, Gómez Amalia, Duro Rosa, Uréndez Ana, Román Miguel
机构信息
Program of Epidemiology and Clinical Research, CIMERA, Fundación Caubet-Cimera Illes Balears, Bunyola, Mallorca, Spain.
出版信息
Prim Care Respir J. 2010 Jun;19(2):140-7. doi: 10.4104/pcrj.2010.00010.
AIMS
We describe the set-up of a population-based study focussed on respiratory conditions, and describe a pilot study - the PULmons SAns Illes Balears (PULSAIB) study - aimed at investigating the natural history of COPD, obstructive sleep apnoea (OSA), and other common chronic diseases.
METHODS
A cross-sectional study was designed to survey two fieldwork areas, one rural and one urban, in the Balearic Islands, Spain. Tests conducted included a questionnaire, spirometry with post-bronchodilator (PBD) test, and portable respiratory polygraphy.
RESULTS
We assessed all processes and tools to be used, and piloted them in 175 participants from Bunyola (rural) and 130 participants from the Son Pizà area (urban). Within this first cross-sectional assessment of the Balearic population aged 30 to 80 years, we report the prevalence of airflow limitation defined as a PBD FEV1/FVC ratio <0.7 and the prevalence of OSA defined as an apnoea-hypopnoea index (AHI) >10/hour.
CONCLUSION
A cohort study in the Balearic population to investigate the natural history of COPD and OSA is feasible.
目的
我们描述了一项以呼吸疾病为重点的基于人群的研究的设置，并介绍了一项试点研究——巴利阿里群岛无慢性阻塞性肺疾病（COPD）、阻塞性睡眠呼吸暂停（OSA）和其他常见慢性病研究（PULmons SAns Illes Balears，PULSAIB），旨在调查慢性阻塞性肺疾病、阻塞性睡眠呼吸暂停和其他常见慢性病的自然史。
方法
设计了一项横断面研究，以调查西班牙巴利阿里群岛的两个实地调查区域，一个农村地区和一个城市地区。进行的测试包括问卷调查、支气管扩张剂后（PBD）肺活量测定和便携式呼吸多导仪检查。
结果
我们评估了所有要使用的流程和工具，并在来自布尼奥拉（农村）的175名参与者和来自索恩皮扎地区（城市）的130名参与者中进行了试点。在对巴利阿里群岛30至80岁人群的首次横断面评估中，我们报告了定义为PBD FEV1/FVC比值<0.7的气流受限患病率以及定义为呼吸暂停低通气指数（AHI）>10/小时的阻塞性睡眠呼吸暂停患病率。
结论
在巴利阿里群岛人群中进行一项队列研究以调查慢性阻塞性肺疾病和阻塞性睡眠呼吸暂停的自然史是可行的。
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