Sawatzki M, Kummer O, Krähenbühl S, Siegemund M
Medizinische Klinik, Universitätsspital Basel, Basel, Schweiz.
Internist (Berl). 2010 Apr;51(4):528-32. doi: 10.1007/s00108-009-2544-2.
We report a case of severe intoxication with extended-release verapamil. In addition to cardiovascular toxicities with hypotension, atrioventricular block and bradycardia, the patient suffered from grand-mal seizure and pulmonary edema 13 and 48 hours respectively, after ingestion of 4.8 g of extended-release verapamil. Adverse reactions after intoxications with extended-release tablets appear delayed with prolonged manifestation of symptoms. Early and repetitive administration of activated charcoal and antegrade whole bowel lavage are crucial, even in primary asymptomatic patients.
我们报告一例缓释维拉帕米严重中毒病例。除了出现伴有低血压、房室传导阻滞和心动过缓的心血管毒性外,该患者在摄入4.8克缓释维拉帕米后分别于13小时和48小时出现癫痫大发作和肺水肿。缓释片中毒后的不良反应出现延迟,症状表现持续时间延长。即使是最初无症状的患者,早期反复给予活性炭和全肠道灌洗也至关重要。