Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, ON, Canada.
Amino Acids. 2011 Nov;41(5):1123-34. doi: 10.1007/s00726-010-0499-1. Epub 2010 Feb 19.
Peptide-based molecular beacons are Förster resonance energy transfer-based target-activatable probes. They offer control of fluorescence emission in response to specific cancer targets and thus are useful tools for in vivo cancer imaging. With our increasing knowledge about human genome in health and disease, peptide-based "smart" probes are continually developed for in vivo optical imaging of specific molecular targets, biological pathways and cancer progression and diagnosis. A class of fluorescent photosensitizers further extends the application of peptide beacons to cancer therapeutics. This review highlights the applications of peptide beacons in cancer imaging, the simultaneous treatment and response monitoring and smart therapeutics with a focus on recent improvements in the design of these probes.
基于肽的分子信标是基于Förster 共振能量转移的靶激活探针。它们可以控制荧光发射，以响应特定的癌症靶标，因此是用于体内癌症成像的有用工具。随着我们对健康和疾病中的人类基因组的了解不断增加，基于肽的“智能”探针不断被开发出来，用于体内特定分子靶标、生物途径和癌症进展及诊断的光学成像。一类荧光光敏剂进一步扩展了肽信标的应用范围，使其应用于癌症治疗。本文综述了肽信标在癌症成像、联合治疗和响应监测以及智能治疗中的应用，重点介绍了这些探针设计的最新进展。
