Ohlsson R, Pfeifer-Ohlsson S
Båda laboratoriet för molekylär utvecklings- och tumörbiologi, Karolinska sjukhuset, Stockholm.
Lakartidningen. 1991 Mar 20;88(12):1087-90.
When the mammalian oocyte is fertilized, a unit is formed which requires the collaboration of the parental cell genomes. In this collaboration, however, a fraction of the autosomal parental genes are provided with different values by a memory from the germ cell maturation process. In the article the importance of genomic imprinting by the parental cell genomes is discussed in terms of the regulation of embryonic development and with regard to tumourigenesis.
当哺乳动物的卵母细胞受精时,会形成一个需要亲代细胞基因组协同作用的单元。然而,在这种协同作用中,一部分常染色体亲代基因因生殖细胞成熟过程中的记忆而具有不同的值。在本文中,从胚胎发育的调控以及肿瘤发生的角度讨论了亲代细胞基因组进行基因组印记的重要性。