Burgess Scott W, Sly Peter D, Devadason Sunalene G
Department of Paediatrics, Redland Hospital, Brisbane, Queensland, 4163 Australia.
J Asthma. 2010 Mar;47(2):198-201. doi: 10.3109/02770900903483840.
This study investigates the impact of measuring adherence and providing feedback on medication usage by children with unstable asthma. Adherence was measured using an electronic monitoring device. Subjects were randomized to either being told of their adherence during review consultations or for their adherence to remain undisclosed to their parents and treating physician. Subjects were reviewed monthly for 4 months. Twenty-six children aged between 6 and 14 years were recruited. Adherence was significantly higher in the intervention group (79% versus 58%, p <.01). There were significant improvements in clinical measures of disease control compared with baseline in both groups. The change in forced expiratory volume in 1 s (FEV(1)) (% predicted) was greater in those subjects receiving feedback (13.8% versus 9.8%). However, lung function values were lower in the intervention group at baseline and the relative improvement failed to reach statistical significance. Measuring adherence and providing feedback increases the use of preventive medication. A larger study is required to explore implications for disease control.
本研究调查了测量依从性并提供关于不稳定哮喘患儿用药反馈的影响。使用电子监测设备测量依从性。受试者被随机分为两组,一组在复诊时被告知其依从性情况,另一组其依从性情况对父母和治疗医生保密。受试者每月接受复查,为期4个月。招募了26名年龄在6至14岁之间的儿童。干预组的依从性显著更高(79%对58%,p<.01)。与基线相比,两组的疾病控制临床指标均有显著改善。接受反馈的受试者一秒用力呼气量(FEV(1))(预测值%)的变化更大(13.8%对9.8%)。然而,干预组在基线时的肺功能值较低,相对改善未达到统计学显著性。测量依从性并提供反馈可增加预防性药物的使用。需要进行更大规模的研究来探讨对疾病控制的影响。