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评估哮喘患者吸入疗法的依从性和电子监测设备的出现。

Assessing adherence to inhaled therapies in asthma and the emergence of electronic monitoring devices.

机构信息

Guy's Severe Asthma Centre, Guy's and St Thomas' NHS Trust, London, UK.

School of Immunology and Microbial Sciences, King's College London, London, UK.

出版信息

Eur Respir Rev. 2022 May 25;31(164). doi: 10.1183/16000617.0271-2021. Print 2022 Jun 30.

Abstract

Infrequent use of inhaled corticosteroids (ICS) and/or over-reliance of short-acting β-agonists (SABA) are recognised as key contributors to increased morbidity and mortality in asthma. The most frequent measures of ICS adherence and SABA use rely on patient-reported questionnaires or prescription refill records, neither of which are considered sufficiently reliable. Technological advancements in the development of electronic monitoring of inhaler devices allow for monitoring of use, as well as recording of and feedback on inhaler technique for some devices. Most electronic monitoring devices (EMDs) are paired with a smartphone application, allowing patients to set reminders and display both preventer and reliever use over time. This allows identification of intentional and unintentional ICS non-adherence as well as frequency of SABA use. This information assists clinicians in distinguishing difficult-to-control from severe asthma. Although additional evidence is required to assess the impact of EMDs on clinical outcome measures such as exacerbation rate, the introduction of EMDs into the asthma armoury is a significant step forward in asthma care with the potential to improve asthma-related outcomes.

摘要

不频繁使用吸入性皮质类固醇(ICS)和/或过度依赖短效β-激动剂(SABA)被认为是导致哮喘发病率和死亡率增加的关键因素。ICS 依从性和 SABA 使用最常用的衡量标准依赖于患者报告的问卷或处方补充记录,这两者都被认为不够可靠。吸入器设备电子监测技术的进步允许监测使用情况,并记录和反馈一些设备的吸入器技术。大多数电子监测设备(EMD)都与智能手机应用程序配对,允许患者设置提醒,并随着时间的推移显示预防器和缓解器的使用情况。这可以识别出有意和无意的 ICS 不依从以及 SABA 使用的频率。这些信息有助于临床医生区分难以控制的哮喘和严重哮喘。尽管需要更多证据来评估 EMD 对临床结果测量(如加重率)的影响,但 EMD 在哮喘治疗中的引入是哮喘治疗的重要一步,有可能改善与哮喘相关的结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd8d/9488666/014c86f44081/ERR-0271-2021.01.jpg

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