Department of Obstetrics and Gynecology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Gynecol Endocrinol. 2010 Jun;26(6):423-8. doi: 10.3109/09513591003632217.
In view of the controversies about the skewed X chromosome inactivation (XCI) and premature ovarian failure (POF) association, a meta-analysis of the published data was performed to evaluate the relationship between XCI skewing and POF.
We searched for all published articles indexed in MEDLINE (1950 approximately 2009) and CNKI (1994 approximately 2009). Any case-control or cohort study that tested the association between skewed XCI and POF was included and data were extracted independently by two reviewers. We performed this meta-analysis involving 325 cases and 403 controls with Review Manager 4.2 software.
Four eligible studies were selected for meta-analysis. It suggested that there was no significant difference between the incidence of skewed XCI (XCI >or=70% skewing) in POF cases comparing to healthy controls, odds ratio (OR) = 1.13 [95% confidence interval (CI): 0.84 approximately 1.53, P = 0.42]. The link between extremely skewed XCI (XCI >or=90% skewing) and POF was also analysed, and no significant difference was found, either, OR = 1.46 (95% CI: 0.79 approximately 2.69, P = 0.22).
Skewed XCI had no association with POF. However, more case-control and cohort studies are needed in the future.
鉴于关于偏斜的 X 染色体失活（XCI）和卵巢早衰（POF）相关性的争议，我们对已发表的数据进行了荟萃分析，以评估 XCI 偏斜与 POF 之间的关系。
我们检索了 MEDLINE（1950 年至 2009 年）和中国知网（1994 年至 2009 年）中索引的所有已发表文章。纳入了所有检验 XCI 偏斜与 POF 之间相关性的病例对照或队列研究，并由两名评审员独立提取数据。我们使用 Review Manager 4.2 软件对涉及 325 例病例和 403 例对照的这一荟萃分析进行了处理。
选择了四项符合条件的研究进行荟萃分析。结果表明，POF 病例中 XCI 偏斜（XCI>或=70%偏斜）的发生率与健康对照者相比无显著差异，比值比（OR）=1.13（95%置信区间[CI]：0.84 至 1.53，P=0.42）。我们还分析了 XCI 极度偏斜（XCI>或=90%偏斜）与 POF 之间的关联，同样未发现显著差异，OR=1.46（95% CI：0.79 至 2.69，P=0.22）。
XCI 偏斜与 POF 无关。但是，未来还需要更多的病例对照和队列研究。
