Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA.
Int J Hyperthermia. 2010;26(3):283-93. doi: 10.3109/02656730903286214.
The purpose of this review is to examine the roles that functional imaging may play in prediction of treatment response and determination of overall prognosis in patients who are enrolled in thermotherapy trials, either in combination with radiotherapy, chemotherapy or both. Most of the historical work that has been done in this field has focused on magnetic resonance imaging/magnetic resonance spectroscopy (MRI/MRS) methods, so the emphasis will be there, although some discussion of the role that positron emission tomography (PET) might play will also be examined. New optical technologies also hold promise for obtaining low cost, yet valuable physiological data from optically accessible sites. The review is organised by traditional outcome parameters: local response, local control and progression-free or overall survival. Included in the review is a discussion of future directions for this type of translational work.
本次综述的目的是探讨功能成像在热疗试验中接受放疗、化疗或联合治疗的患者的治疗反应预测和整体预后判断方面可能发挥的作用。该领域的大部分历史研究都集中在磁共振成像/磁共振波谱（MRI/MRS）方法上，因此将重点介绍这些方法，但也将探讨正电子发射断层扫描（PET）可能发挥的作用。新的光学技术也有望从可光学访问的部位获得低成本但有价值的生理数据。该综述按照传统的疗效参数进行组织：局部反应、局部控制、无进展生存或总生存。其中还讨论了这种转化工作的未来方向。
