Räägel Helin, Säälik Pille, Pooga Margus
Institute of Molecular and Cell Biology, University of Tartu, Estonia.
Biochim Biophys Acta. 2010 Dec;1798(12):2240-8. doi: 10.1016/j.bbamem.2010.02.013. Epub 2010 Feb 17.
The growing number of reports on the effective cargo delivery by cell-penetrating peptides (CPPs) has extensively widened our knowledge about the mechanisms involved in CPP-mediated delivery. However, the data available on the internalization mode of CPP-cargo complexes are often conflicting and/or equivocal. Moreover, the intracellular trafficking of CPP-cargo complexes is, to date, relatively unexplored resulting in only minimal information about what is really happening to the complexes inside the cell. This review focuses on defining the endocytic pathways engaged in the transduction of CPP-cargo complexes and seeks to determine the extent of different endocytic routes required for effective uptake. In addition, the intracellular pathways utilized during the trafficking and sorting of CPP-cargo complexes as well as the ultimate fate of the complexes inside cells will be discussed.
关于细胞穿透肽（CPPs）有效递送货物的报道日益增多，极大地拓宽了我们对CPP介导递送所涉及机制的认识。然而，关于CPP-货物复合物内化模式的现有数据往往相互矛盾和/或含糊不清。此外，迄今为止，CPP-货物复合物的细胞内运输相对未被探索，导致关于细胞内复合物实际情况的信息极少。本综述着重于确定参与CPP-货物复合物转导的内吞途径，并试图确定有效摄取所需的不同内吞途径的程度。此外，还将讨论CPP-货物复合物运输和分选过程中利用的细胞内途径以及细胞内复合物的最终命运。
