Sun Huaying, Che Yi, Liu Xiaofen, Ma Yuanye
State Key Laboratory of Brain and Cognitive Science, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, PR China.
Int J Dev Neurosci. 2010 May;28(3):239-43. doi: 10.1016/j.ijdevneu.2010.02.001. Epub 2010 Feb 17.
The central nervous system exhibits remarkable plasticity in early life. Prenatal morphine exposure may induce adverse behavioral effects on the neonate and the developing offspring. In the present study, we investigated the effect of prenatal morphine exposure (daily from embryonic days 12-16, 20mg/kg) on 11-day-old chicks using two forms of spatial paradigms: one trial detour behavior task in which animals must bypass an obstacle to reach the desired goal without any training and detour learning task which required several trials of training to reach the detour criterion. The results showed that, on the condition that chicks could successfully detour in the first trial, morphine exposed chicks exhibited longer detour latency to finish the task, coupled by a preference for turning right versus turning left. In contrast, no significant difference in learning and memory was found in detour learning task between morphine exposed chicks and saline chicks. These findings suggest specific behavioral changes associated with prenatal exposure to opioids during mid to late gestation, also raise attention to the possible health hazard from pregnancy drug use in everyday life.
中枢神经系统在生命早期表现出显著的可塑性。产前接触吗啡可能会对新生儿和发育中的后代产生不良行为影响。在本研究中，我们使用两种空间范式研究了产前接触吗啡（从胚胎第12天至16天，每天20mg/kg）对11日龄雏鸡的影响：一种是单次试验迂回行为任务，即动物无需任何训练就必须绕过障碍物以到达期望的目标；另一种是迂回学习任务，需要经过几次训练试验才能达到迂回标准。结果表明，在雏鸡能够在第一次试验中成功迂回的情况下，接触吗啡的雏鸡完成任务的迂回潜伏期更长，且偏好向右转而非向左转。相比之下，在迂回学习任务中，接触吗啡的雏鸡和生理盐水处理的雏鸡在学习和记忆方面没有显著差异。这些发现表明，妊娠中后期产前接触阿片类药物会导致特定的行为变化，也引起了人们对日常生活中孕期用药可能带来的健康危害的关注。
