Slamberová R, Riley M A, Vathy I
Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, 1300 Morris Park Ave., Ull. 111, Bronx, NY 10461, USA.
Physiol Res. 2005;54(6):655-60.
Prenatal exposure to opiates can have devastating effects on the development of human fetuses and may induce long-term physical and neurobehavioral changes during postnatal maturation. The present study was aimed at identifying cross-generational effects of prenatal morphine exposure in Sprague-Dawley rats. Pregnant rats were injected subcutaneously with either saline or morphine (10 mg/kg) twice daily during gestational days 11-18. Litter size, percentage of males and females, anogenital distances (AGDs), righting reflex, and body weight were assessed in prenatally morphine-exposed pups (first generation) and their offspring (second generation). Both prenatally morphine-exposed pups and offspring of prenatally morphine-exposed dams exhibited an increased latency to right. Additionally, second generation pups were slower in righting than first generation pups. During the early postnatal period the second generation pups weighed less than the first generation regardless of drug exposure. The AGDs of second generation male pups were decreased relative to the first generation. Our data provide important novel information about the trans-generational effects of maternal opiate abuse that may be useful for understanding/evaluating the teratogenic effects of prenatal opiate exposure.
产前接触阿片类药物会对人类胎儿的发育产生毁灭性影响，并可能在产后成熟过程中引发长期的身体和神经行为变化。本研究旨在确定产前吗啡暴露对斯普拉格-道利大鼠的跨代影响。在妊娠第11至18天，对怀孕大鼠每天皮下注射两次生理盐水或吗啡（10毫克/千克）。对产前暴露于吗啡的幼崽（第一代）及其后代（第二代）评估窝仔数、雄性和雌性比例、肛门生殖器距离（AGD）、翻正反射和体重。产前暴露于吗啡的幼崽及其产前暴露于吗啡的母鼠的后代均表现出翻正潜伏期延长。此外，第二代幼崽的翻正速度比第一代幼崽慢。在出生后早期，无论是否接触药物，第二代幼崽的体重都比第一代轻。第二代雄性幼崽的AGD相对于第一代有所减小。我们的数据提供了关于母体阿片类药物滥用跨代影响的重要新信息，这可能有助于理解/评估产前阿片类药物暴露的致畸作用。
