Institute of General Food Chemistry, Technical University of Łódź, ul. Stefanowskiego 4/10, 90-924 Łódź, Poland.
J Inorg Biochem. 2010 May;104(5):570-5. doi: 10.1016/j.jinorgbio.2010.01.009. Epub 2010 Jan 28.
Copper(II) complexes of histamine modified 2'-deoxyriboadenosine (N-[(9-beta-D-2'-deoxyribofuranosylpurin-6-yl)-carbamoyl]histamine) ligand were studied by potentiometric, UV-visible and EPR techniques. The imidazole residue of the ligand was described as the main binding site forming mono-, bis-(ligand) and dimer complexes, but the interactions between adenosine nitrogen N(1) and carbamoyl nitrogen atoms and the copper(II) ion also were detected. This is the first report evaluating the coordinating ability of such a modified adenosine ligand towards copper(II) ion. Our findings suggest that histamine modified 2'-deoxyriboadenosine could chelate efficiently copper(II) ions if it were incorporated into DNAzyme sequence.
组胺修饰的 2'-脱氧腺苷（N-[(9-β-D-2'-脱氧呋喃核糖基嘌呤-6-基）-氨甲酰基]组胺）配体的铜（II）配合物通过电位法、紫外可见和电子顺磁共振技术进行了研究。配体的咪唑残基被描述为形成单核、双（配体）和二聚体配合物的主要结合位点，但也检测到了腺苷氮 N(1)和氨甲酰氮原子与铜（II）离子之间的相互作用。这是首次评估这种修饰的腺苷配体对铜（II）离子的配位能力的报告。我们的研究结果表明，如果将组胺修饰的 2'-脱氧腺苷整合到 DNAzyme 序列中，它可以有效地螯合铜（II）离子。
