Department of Anesthesia, American Hospital, Dubai, United Arab Emirates.
J Arthroplasty. 2011 Jan;26(1):24-8. doi: 10.1016/j.arth.2009.11.013. Epub 2010 Feb 19.
The effects of 2-dosage regimens of tranexamic acid (10 mg/kg and 15 mg/kg) on blood loss and transfusion requirement were compared to saline placebo in 60 patients undergoing concurrent bilateral total knee arthroplasty, with additional reinfusion autotransfusion from intraarticular drains. Mean blood loss was 462 mL in 15 mL/kg group, 678 mL in 10 mg/kg group, and 918 mL in controls (P < .01 vs 15 mg/kg). Blood available for autotransfusion was greatest in controls and least in 15 mg/kg group. Combined autologous and allogenic transfusion volumes were similar in the treatment groups and significantly less than controls (P < .01). With use of an autologous reinfusion strategy, the lower dose is sufficient to lead to a lesser allogenic transfusion requirement.
在 60 例行双侧全膝关节置换术的患者中，比较了两种剂量的氨甲环酸（10mg/kg 和 15mg/kg）与生理盐水安慰剂对失血和输血需求的影响，并从关节内引流管中进行了再输注自体输血。15mg/kg 组平均失血量为 462mL，10mg/kg 组为 678mL，对照组为 918mL（P<0.01 比 15mg/kg 组）。可用于自体输血的血量在对照组中最多，在 15mg/kg 组中最少。治疗组的联合自体和同种异体输血量与对照组相似，明显少于对照组（P<0.01）。使用自体再输注策略时，较低剂量即可减少异体输血需求。
