Institute of Preventive Medicine, College of Public Health, National Taiwan University, No. 17 Xu-Zhou Road, Taipei, Taiwan.
Arch Gerontol Geriatr. 2010 Feb;50 Suppl 1:S48-52. doi: 10.1016/S0167-4943(10)70013-3.
BMI change and BMI at an early age have not been investigated as risks for dementia. This case-control study included 286 dementia patients and 268 controls from two medical centers between 2007 and 2009. BMI information was collected from medical records and questionnaires. Men and women with low BMIs at the time of the study, in their 20s, and in their 40s had significantly increased risks of Alzheimer's disease (AD) (odds ratio = OR = 2.62-3.97) and increased vascular dementia (VaD) risk (20s and 40s: OR = 6.23-11.11) compared with those with normal BMIs. High BMI in the 20s and 40s was associated with increased VaD risk (OR = 15.29 and 10.32) among women. For BMI changes from the 20s or 40s, the second and third tertiles were significantly associated with decreased AD risk among women (OR = 0.15-0.35) compared to the first tertile. The third tertile of BMI change from the 20s or 40s was associated with decreased VaD risk among women (OR = 0.06 and 0.14). Low BMIs in the 20s and 40s were stronger predictors of AD and VaD. There was a U-shaped association between BMI at different ages and dementia among participants with VaD.
体重指数（BMI）变化和年轻时的 BMI 尚未被研究为痴呆的风险因素。本病例对照研究纳入了 2007 年至 2009 年间来自两个医学中心的 286 名痴呆症患者和 268 名对照。BMI 信息来自病历和问卷调查。在研究时、20 多岁和 40 多岁时 BMI 较低的男性和女性患阿尔茨海默病（AD）（比值比 [OR] = 2.62-3.97）和血管性痴呆（VaD）的风险显著增加（20 多岁和 40 多岁：OR = 6.23-11.11），与 BMI 正常的患者相比。20 多岁和 40 多岁时 BMI 较高与女性 VaD 风险增加相关（OR = 15.29 和 10.32）。对于 20 多岁或 40 多岁的 BMI 变化，与女性 AD 风险降低相关的第二和第三 tertile 显著相关（OR = 0.15-0.35），与第一 tertile 相比。20 多岁或 40 多岁 BMI 变化的第三 tertile 与女性 VaD 风险降低相关（OR = 0.06 和 0.14）。20 多岁和 40 多岁时 BMI 较低是 AD 和 VaD 的更强预测因素。在 VaD 患者中，不同年龄的 BMI 与痴呆之间存在 U 形关联。
