Department of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
J Clin Densitom. 2010 Jan-Mar;13(1):24-28. doi: 10.1016/j.jocd.2009.09.007.
Osteoarthritis (OA) is a common disease that increases in incidence with age and currently affects an estimated 27 million Americans. To determine whether site-specific hip bone mineral density (BMD) measures are confounded by the presence of OA, we measured bilateral hip BMD by dual X-ray absorptiometry in 34 subjects (19 women and 15 men) scheduled for hip replacement for confirmed advanced unilateral hip OA. The femoral neck (FN) BMD (p=0.035) and T-score (p=0.017) for the hip with OA was higher than those of the contralateral hip. There was a difference in osteoporosis classification depending on which hip was considered: for 11 of the 34 subjects (32%), the FN T-score was normal for OA hip, but the contralateral hip was classified as osteopenic (T-score between -1.0 and -2.5). For 1 subject, the FN T-score was normal for OA hip, but the contralateral hip was classified as osteoporotic (T-score below -2.5). Discordance was also present for trochanter values and not for total hip values. These data indicate that advanced hip OA can be associated with a higher bone density at the FN and trochanter but not at total hip and that the discrepancy between hips at the FN may have an impact on patient treatment decisions.
骨关节炎（OA）是一种常见疾病，其发病率随年龄增长而增加，目前估计有 2700 万美国人受到影响。为了确定特定部位髋关节骨密度（BMD）是否受到 OA 的影响，我们对 34 名计划接受髋关节置换术以治疗确诊的单侧髋关节 OA 患者的双侧髋关节进行了双能 X 线吸收法测量。OA 髋关节的股骨颈（FN）BMD（p=0.035）和 T 评分（p=0.017）均高于对侧髋关节。根据考虑的髋关节不同，骨质疏松症的分类也存在差异：在 34 名受试者中，有 11 名（32%）的 FN T 评分对 OA 髋关节正常，但对侧髋关节被归类为骨量减少（T 评分在-1.0 和-2.5 之间）。对于 1 名受试者，OA 髋关节的 FN T 评分正常，但对侧髋关节被归类为骨质疏松症（T 评分低于-2.5）。转子间值也存在差异，而全髋关节值不存在差异。这些数据表明，晚期髋关节 OA 可能与 FN 和转子间骨密度较高相关，但与全髋关节无关，且 FN 处髋关节之间的差异可能会影响患者的治疗决策。
