台湾一家医学中心医护人员对大流行（H1N1）2009 流感病毒抗体的血清阳性率。
Seroprevalence of antibodies to pandemic (H1N1) 2009 influenza virus among hospital staff in a medical center in Taiwan.
机构信息
Division of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
出版信息
J Chin Med Assoc. 2010 Feb;73(2):62-6. doi: 10.1016/S1726-4901(10)70003-4.
BACKGROUND
The pandemic (H1N1) 2009 influenza emerged in April 2009 and spread rapidly and broadly all over the world. In addition to specific antiviral agents, massive vaccination is thought to be the most effective way of controlling the transmission. To understand the prevaccination status of certain risk groups, this study compared the baseline sero-prevalence of antibodies to the pandemic (H1N1) 2009 influenza virus among hospital staff with different contact risks and that of the general population.
METHODS
A total of 295 serum samples from hospital staff and 244 control serum samples from people who came for physical check-up (control group) were collected between October 2009 and November 2009 before the massive vaccination campaign. The hospital staff was divided into first-line risk personnel (group 1) and second-line risk personnel (group 2) according to their potential contact risks. Hemagglutination-inhibition (HI) tests were conducted to determine the individual serological status. The seropositive rate (SPR, defined as the proportion with HI titer >/= 1:40) of antibodies to H1N1 influenza virus and its geometric mean titer (GMT) were calculated and compared among the different groups.
RESULTS
The mean ages and sex ratio (% male) of the hospital staff and control groups were 36.9 +/- 10.6 years and 52.0 +/- 12.6 years, and 24.4% and 57.6%, respectively. The SPR of the antibodies to H1N1 influenza virus of the hospital staff was significantly higher than that of the control group (20.0%vs. 2.9%, p < 0.001). Furthermore, the SPR antibodies to H1N1 influenza virus of group 1 were significantly higher than that of group 2 (30.8%vs. 12.6%, p < 0.001). However, the GMT of antibodies to H1N1 influenza virus of the hospital staff was not significantly different from that of the control group (p = 0.925).
CONCLUSION
The SPR of antibodies against the pandemic (H1N1) 2009 virus in the hospital staff was higher than that in the general population, reflecting a higher contact risk. Prevaccination surveillance of the immune status of different risk groups may help to prioritize which groups should be vaccinated first.
背景
2009 年甲型 H1N1 流感大流行于 2009 年 4 月出现，迅速在全球广泛传播。除了特定的抗病毒药物外，大规模疫苗接种被认为是控制传播的最有效方法。为了了解特定风险人群的接种前状况，本研究比较了具有不同接触风险的医院工作人员与一般人群中对大流行（H1N1）2009 流感病毒的抗体基线血清阳性率。
方法
2009 年 10 月至 11 月大规模疫苗接种前，共采集 295 份医院工作人员血清样本和 244 份体检人群血清样本（对照组）。根据潜在接触风险，将医院工作人员分为一线风险人员（第 1 组）和二线风险人员（第 2 组）。采用血凝抑制（HI）试验测定个体血清学状况。计算并比较不同组之间对 H1N1 流感病毒抗体的血清阳性率（SPR，定义为 HI 滴度> = 1:40 的比例）及其几何平均滴度（GMT）。
结果
医院工作人员和对照组的平均年龄和性别比（%男性）分别为 36.9 +/- 10.6 岁和 52.0 +/- 12.6 岁，分别为 24.4%和 57.6%。医院工作人员对 H1N1 流感病毒抗体的 SPR 明显高于对照组（20.0%vs. 2.9%，p < 0.001）。此外，第 1 组对 H1N1 流感病毒抗体的 SPR 明显高于第 2 组（30.8%vs. 12.6%，p < 0.001）。然而，医院工作人员对 H1N1 流感病毒抗体的 GMT 与对照组无显著差异（p = 0.925）。
结论
医院工作人员对大流行（H1N1）2009 病毒抗体的 SPR 高于一般人群，反映出较高的接触风险。对不同风险人群免疫状况的接种前监测可能有助于确定应优先接种哪些人群。
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