Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Nanomedicine. 2010 Oct;6(5):689-97. doi: 10.1016/j.nano.2010.01.011. Epub 2010 Feb 18.
UNLABELLED: The aim of the present work was to prepare and characterize poly(methyl methacrylate) nanoparticles coated by chitosan-glutathione conjugate so as to encapsulate insoluble anticancer drugs. Nanoparticles were synthesized through radical polymerization of methyl methacrylate initiated by cerium (IV) ammonium nitrate. Paclitaxel (PTX), a model anticancer drug, was encapsulated in nanoparticles with a maximal encapsulation efficiency of 98.27%. These nanoparticles showed sustained in vitro release of the incorporated PTX (75% of the loaded dose was released in 10 days). All nanoparticles had positive charge and were spherical, with a size range of about 130-250 nm. The PTX-loaded nanoparticles showed cytotoxicity for NIH 3T3 and T47D breast carcinoma cells, along with no cytotoxicity for two colon cell lines (HT29, Caco2). FROM THE CLINICAL EDITOR: The aim of this work was to prepare and characterize poly(methyl methacrylate) nanoparticles coated by chitosan-glutathione conjugate in an effort to encapsulate Paclitaxel as a model of insoluble anticancer drugs. These nanoparticles showed sustained in vitro drug release.
未加标签：本工作旨在制备并表征壳聚糖-谷胱甘肽缀合物包覆的聚甲基丙烯酸甲酯纳米粒子，以包裹难溶性抗癌药物作为模型药物。纳米粒子通过硝酸铈(IV)铵引发的甲基丙烯酸甲酯自由基聚合合成。紫杉醇（PTX）是一种模型抗癌药物，其包封效率最高可达 98.27%。这些纳米粒子表现出对所载 PTX 的持续体外释放（10 天内释放了 75%的载药量）。所有纳米粒子均带正电荷，呈球形，粒径约为 130-250nm。载有 PTX 的纳米粒子对 NIH 3T3 和 T47D 乳腺癌细胞具有细胞毒性，而对两种结肠细胞系（HT29、Caco2）没有细胞毒性。
临床编辑按：本工作旨在制备并表征壳聚糖-谷胱甘肽缀合物包覆的聚甲基丙烯酸甲酯纳米粒子，以包裹紫杉醇作为难溶性抗癌药物的模型药物。这些纳米粒子显示出持续的体外药物释放。
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