Scientific Institute of Public Health, Department Food, Medicines and Consumer Safety, J. Wytsmanstraat 14, B-1050 Brussels, Belgium.
Anal Chim Acta. 2010 Mar 17;663(1):55-9. doi: 10.1016/j.aca.2010.01.044. Epub 2010 Feb 1.
Benzophenone (BP) and 4-methylbenzophenone (4MBP) are photo-initiators that are generally used to cure ink on carton boards. In this contribution, a fast and reliable method for the determination of BP and 4MBP in breakfast cereals is described. The sample was extracted ultrasonically using a mixture of dichloromethane and acetonitrile (1:1), followed by a clean-up of the extract using solid phase extraction with a silica cartridge. Finally, the extract was analysed by GC-MS(n). Benzophenone-d(10) was used as internal standard. The presented method is validated in terms of linearity, recovery, repeatability and intra-laboratory reproducibility, specificity, limit of detection and limit of quantification. In conclusion, this method is able to detect both BP and 4MBP at very low concentrations (LOD=2microg kg(-1)) in breakfast cereals.
二苯甲酮（BP）和 4-甲基二苯甲酮（4MBP）是光引发剂，通常用于固化纸盒上的油墨。本研究介绍了一种快速可靠的测定早餐谷物中二苯甲酮和 4-甲基二苯甲酮的方法。样品经二氯甲烷和乙腈（1:1）混合超声提取，然后用硅胶固相萃取柱净化。最后，采用 GC-MS(n)进行分析。以苯甲酮-d10 作为内标。本方法在线性、回收率、重复性和实验室间重现性、特异性、检出限和定量限方面进行了验证。该方法能够在早餐谷物中非常低的浓度（LOD=2μg/kg）下检测到二苯甲酮和 4-甲基二苯甲酮。
