Mori H, Sugie S, Okumura A, Hara A, Kinouchi T, Kataoka K, Ohnishi Y
Department of Pathology, Gifu University School of Medicine, Japan.
Mutat Res. 1991 Apr;262(4):233-8. doi: 10.1016/0165-7992(91)90089-m.
The genotoxicity of a pyrene oxide, 1-nitropyrene (NP) oxides and other related compounds was examined in the hepatocyte primary culture (HPC)/DNA repair test. Pyrene 4,5-oxide and both 1-NP-4,5-oxide and 1-NP-9,10-oxide elicited clearly positive responses of DNA repair. In this assay, 1-NP itself was weakly positive. However, other related chemicals such as pyrene, 1-nitro-3-hydroxypyrene, 1-nitro-6-hydroxypyrene, and 1-nitro-8-hydroxypyrene did not generate positive responses.
在肝细胞原代培养（HPC）/DNA修复试验中检测了氧化芘、1-硝基芘（NP）氧化物及其他相关化合物的遗传毒性。芘4,5-氧化物以及1-NP-4,5-氧化物和1-NP-9,10-氧化物均引发了明显的DNA修复阳性反应。在该试验中，1-NP本身呈弱阳性。然而，其他相关化学物质，如芘、1-硝基-3-羟基芘、1-硝基-6-羟基芘和1-硝基-8-羟基芘并未产生阳性反应。
