介入性支气管镜检查从实验室到临床：早期肺癌检测的新技术。

Interventional bronchoscopy from bench to bedside: new techniques for early lung cancer detection.

机构信息

Department of Medicine, Pulmonary and Critical Care Medicine, University of California School of Medicine, 101 The City Drive, Irvine, Orange, CA 92868, USA.

出版信息

Clin Chest Med. 2010 Mar;31(1):29-37, Table of Contents. doi: 10.1016/j.ccm.2009.09.001.

DOI:10.1016/j.ccm.2009.09.001

PMID:20172430

Abstract

Lung cancer is a leading cause of cancer-related death in the world, and it accounts for more deaths than breast, colon, and prostate cancer combined in the United States. From a historical perspective, the premise behind early lung cancer detection strategy is that early detection of lung cancer is justified if early treatment improves the outcome. New optical technologies such as those presented in this article allow dynamic study of these processes at the cellular level, and it is hoped that opportunities for targeted therapy will be provided in the future. Investigators are on the verge of discovering a multidimensional bronchoscopic platform that can be used to narrow in on airway structures, explore vascular flow and angiogenesis, and discover new features of bronchogenic carcinogenesis.

摘要

肺癌是全球癌症相关死亡的主要原因，在美国，肺癌导致的死亡人数超过了乳腺癌、结肠癌和前列腺癌死亡人数的总和。从历史上看，早期肺癌检测策略的前提是，如果早期治疗能改善结果，那么早期发现肺癌是合理的。本文介绍的新光学技术可以在细胞水平上对这些过程进行动态研究，人们希望未来能提供针对这些过程的靶向治疗机会。研究人员即将发现一种多维支气管镜平台，可以用于缩小气道结构、探索血管流动和血管生成，并发现支气管癌发生的新特征。