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早期近端肺癌的诊断与治疗。

Early proximal lung cancer diagnosis and treatment.

作者信息

McWilliams A, Lam B, Sutedja T

机构信息

University of British Columbia, British Columbia Cancer Agency and Vancouver General Hospital, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada.

出版信息

Eur Respir J. 2009 Mar;33(3):656-65. doi: 10.1183/09031936.00124608.

Abstract

Lung cancer remains the largest cause of cancer deaths worldwide and the overall 5-yr survival rate is only 15%. This is because the majority of the lung cancers are diagnosed at late stages and the treatment outcome is suboptimal. However, the survival of patients with early stage proximal lung cancer is excellent and with advancements in technology we are currently well equipped to diagnose and stage these lung cancers. Together with the application of local bronchoscopic therapeutic modalities that may potentially cure early stage intraluminal lesions, there is expanding interest in the further exploration of new avenues for early detection, localisation, staging, treatment and close surveillance of these high-risk patients who are suffering from chronic field carcinogenesis. The present article will deal with various issues regarding early detection, staging and treatment of centrally located early stage, mostly squamous type, lung cancer.

摘要

肺癌仍是全球癌症死亡的首要原因,总体5年生存率仅为15%。这是因为大多数肺癌在晚期才被诊断出来,治疗效果欠佳。然而,早期近端肺癌患者的生存率很高,随着技术的进步,我们目前有充分的条件来诊断这些肺癌并进行分期。再加上应用局部支气管镜治疗方式可能治愈早期腔内病变,人们越来越有兴趣进一步探索新途径,以便对这些患有慢性区域致癌作用的高危患者进行早期检测、定位、分期、治疗和密切监测。本文将探讨有关中央型早期(大多为鳞状细胞型)肺癌的早期检测、分期和治疗的各种问题。

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