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本文引用的文献

1
High-resolution imaging of brain 5-HT 1B receptors in the rhesus monkey using [11C]P943.使用[11C]P943 对恒河猴大脑 5-HT1B 受体进行高分辨率成像。
Nucl Med Biol. 2010 Feb;37(2):205-14. doi: 10.1016/j.nucmedbio.2009.10.007. Epub 2009 Dec 1.
2
Kinetic modeling of the serotonin 5-HT(1B) receptor radioligand [(11)C]P943 in humans.人类血清素 5-HT(1B)受体放射性配体 [(11)C]P943 的动力学建模。
J Cereb Blood Flow Metab. 2010 Jan;30(1):196-210. doi: 10.1038/jcbfm.2009.195. Epub 2009 Sep 23.
3
Dynamics of neuronal circuits in addiction: reward, antireward, and emotional memory.成瘾中神经回路的动力学：奖赏、反奖赏与情绪记忆。
Pharmacopsychiatry. 2009 May;42 Suppl 1(Suppl 1):S32-41. doi: 10.1055/s-0029-1216356. Epub 2009 May 11.
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Alterations in brain serotonin synthesis in male alcoholics measured using positron emission tomography.
Alcohol Clin Exp Res. 2009 Feb;33(2):233-9. doi: 10.1111/j.1530-0277.2008.00820.x. Epub 2008 Oct 31.
5
Positron emission tomography imaging of the serotonin transporter and 5-HT(1A) receptor in alcohol dependence.酒精依赖中血清素转运体和5-羟色胺（1A）受体的正电子发射断层扫描成像
Biol Psychiatry. 2009 Jan 15;65(2):175-80. doi: 10.1016/j.biopsych.2008.08.034. Epub 2008 Oct 29.
6
Consensus nomenclature for in vivo imaging of reversibly binding radioligands.可逆结合放射性配体体内成像的共识命名法。
J Cereb Blood Flow Metab. 2007 Sep;27(9):1533-9. doi: 10.1038/sj.jcbfm.9600493. Epub 2007 May 9.
7
5-HT(1B) receptors in nucleus accumbens efferents enhance both rewarding and aversive effects of cocaine.伏隔核传出神经中的5-羟色胺（1B）受体增强了可卡因的奖赏和厌恶作用。
Eur J Neurosci. 2007 May;25(10):3125-31. doi: 10.1111/j.1460-9568.2007.05568.x. Epub 2007 May 17.
8
PET [11C]DASB imaging of serotonin transporters in patients with alcoholism.酗酒患者中血清素转运体的PET [11C]DASB成像
Alcohol Clin Exp Res. 2007 Jan;31(1):28-32. doi: 10.1111/j.1530-0277.2006.00261.x.
9
Increased expression of 5-HT1B receptors in rat nucleus accumbens via virally mediated gene transfer increases voluntary alcohol consumption.通过病毒介导的基因转移增加大鼠伏隔核中5-HT1B受体的表达会增加自愿饮酒量。
Alcohol. 2006 Feb;38(2):73-9. doi: 10.1016/j.alcohol.2006.04.003.
10
Regional expression of 5-HT1B receptor mRNA in the human brain.5-羟色胺1B受体信使核糖核酸在人脑内的区域表达
Synapse. 2005 Apr;56(1):21-8. doi: 10.1002/syn.20128.

酒精依赖的 5-羟色胺 1B 受体显像。

Serotonin 1B receptor imaging in alcohol dependence.

机构信息

Molecular Imaging Program, Clinical Neurosciences Division, VA National Center for PTSD, VA Connecticut Healthcare System, West Haven, Connecticut, USA.

出版信息

Biol Psychiatry. 2010 May 1;67(9):800-3. doi: 10.1016/j.biopsych.2009.12.028. Epub 2010 Feb 20.

DOI:10.1016/j.biopsych.2009.12.028
PMID:20172504
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3112181/
Abstract

BACKGROUND

Although animal models suggest that alcohol dependence (AD) is associated with elevations in the number of serotonin 1B receptors (5-HT(1B)R), 5-HT(1B)R levels have not been investigated in people with AD. The selective 5-HT(1B)R antagonist radioligand, [(11)C]P943, permits in vivo assessment of central 5-HT(1B)R binding potential (BP(ND)) with positron emission tomography. Because of its central role in AD, we were particularly interested in ventral striatal 5-HT(1B)R BP(ND) values.

METHODS

Twelve medication-free, recently abstinent (at least 4 weeks) patients with AD (mean age 35.2 +/- 10.2 years, 5 women) and 12 healthy control subjects (HC) (mean age 30.6 +/- 9.2 years, 5 women) completed [(11)C]P943 positron emission tomography on a high-resolution research tomograph. Individual magnetic resonance imaging scans were collected to exclude individuals with anatomical abnormalities and for coregistration. Imaging data were analyzed with a multilinear reference tissue model.

RESULTS

Ventral striatal 5-HT(1B)R BP(ND) values (2.01 +/- .57% and 1.55 +/- .09%, respectively; 29% between-group difference, p = .006) were increased in AD compared with HC subjects. No influence of demographic or clinical variables or amount of injected radiotracer was observed.

CONCLUSIONS

This study provides the first evidence that AD in humans is, like in rodent models, associated with increased levels of ventral striatal 5-HT(1B)Rs.

摘要

背景

尽管动物模型表明，酒精依赖（AD）与血清素 1B 受体（5-HT1BR）数量的增加有关，但AD 患者的 5-HT1BR 水平尚未得到研究。选择性 5-HT1BR 拮抗剂放射性配体 [(11)C]P943，可通过正电子发射断层扫描进行体内评估中枢 5-HT1BR 结合潜能（BP（ND））。由于其在 AD 中的核心作用，我们特别关注腹侧纹状体 5-HT1BR BP（ND）值。

方法

12 名无药物、近期戒断（至少 4 周）的 AD 患者（平均年龄 35.2 +/- 10.2 岁，5 名女性）和 12 名健康对照者（HC）（平均年龄 30.6 +/- 9.2 岁，5 名女性）在高分辨率研究断层扫描仪上完成了 [(11)C]P943 正电子发射断层扫描。采集个体磁共振成像扫描以排除有解剖异常者，并进行配准。使用多线性参考组织模型分析成像数据。

结果

AD 患者的腹侧纹状体 5-HT1BR BP（ND）值（分别为 2.01 +/-.57%和 1.55 +/-.09%；29%的组间差异，p =.006）高于 HC 组。未观察到人口统计学或临床变量或注射示踪剂数量的影响。

结论

这项研究首次提供了证据，表明人类 AD 与啮齿动物模型一样，与腹侧纹状体 5-HT1BR 水平升高有关。