Division of Orthopaedics, Department of Surgery, Far Eastern Memorial Hospital, Taipei, Taiwan, ROC.
Biomaterials. 2010 May;31(14):4048-55. doi: 10.1016/j.biomaterials.2010.01.124. Epub 2010 Feb 20.
Osteonecrosis of the femoral head commonly occurs when the blood supply to bone was disrupted. The general treatment for early stages of necrosis in the femoral head is core decompression. However, the long-term outcome of this operation is usually compromised due to collapse of the necrotic bone. In this study, poly(propylene fumarate) (PPF) and calcium phosphate cement (CPC) were combined to provide appropriate mechanical strength after core-decompressed femoral heads and offer the properties of osteoconductivity. Effects of different ratios of CPC to PPF on mechanical and cytotoxicity were investigated. Results show that bone cement is less cytotoxic with the C/P ratio raise, and the increment of the CPC proportion also strengthens the mechanical strength, reduces the crosslinking temperature and diminishes excessive swelling of the cement. With addition of ginsenoside Rg1 the bone cement composite can also offer angiogenic effect. The drug release profiles were analyzed and the angiogenecity of released Rg1 was confirmed by the assay of tube formation in human umbilical vein endothelial cells (HUVECs). In summary, the newly developed angiogenic bone cement composite possesses remarkable development potential for application to treating osteonecrosis of the femoral head.
股骨头坏死通常发生在骨的血液供应中断时。股骨头坏死早期的一般治疗方法是核心减压。然而，由于坏死骨的塌陷，这种手术的长期效果通常会受到影响。在这项研究中，聚（富马酸丙二醇酯）（PPF）和磷酸钙骨水泥（CPC）被结合在一起，为核心减压后的股骨头提供适当的机械强度，并提供成骨作用的特性。研究了 CPC 与 PPF 的不同比例对机械性能和细胞毒性的影响。结果表明，骨水泥的细胞毒性随着 C/P 比的升高而降低，CPC 比例的增加也增强了机械强度，降低了交联温度，减少了水泥的过度膨胀。加入人参皂苷 Rg1 后，骨水泥复合材料还能提供血管生成作用。分析了药物释放曲线，并通过人脐静脉内皮细胞（HUVEC）管形成测定证实了释放的 Rg1 的血管生成作用。总之，新开发的血管生成骨水泥复合材料具有显著的发展潜力，可用于治疗股骨头坏死。
