妊娠和分娩期间的宫颈重塑。
Cervical remodeling during pregnancy and parturition.
机构信息
Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75235-9032, USA.
出版信息
Trends Endocrinol Metab. 2010 Jun;21(6):353-61. doi: 10.1016/j.tem.2010.01.011. Epub 2010 Feb 19.
Abstract
Appropriate and timely cervical remodeling is key for successful birth. Premature cervical opening can result in preterm birth which occurs in 12.5% of pregnancies. Research focused on the mechanisms of term and preterm cervical remodeling is essential to prevent prematurity. This review highlights recent findings that better define molecular processes driving progressive disorganization of the cervical extracellular matrix. This includes studies that redefine the role of immune cells and identify diverse functions of the cervical epithelia and hyaluronan in remodeling. New investigations proposing that infection-induced premature cervical remodeling is distinct from the normal process are presented. Recent advances in our understanding of term and preterm cervical remodeling provide new directions for investigation and compel investigators to reevaluate currently accepted models.
摘要
适当和及时的宫颈重塑是成功分娩的关键。宫颈过早张开可导致早产，这在 12.5%的妊娠中发生。针对足月和早产宫颈重塑机制的研究对于预防早产至关重要。这篇综述强调了最近的发现，这些发现更好地定义了驱动宫颈细胞外基质进行性解体的分子过程。这包括重新定义免疫细胞作用的研究，并确定宫颈上皮和透明质酸在重塑中的不同功能。提出感染引起的过早宫颈重塑与正常过程不同的新研究也被呈现。我们对足月和早产宫颈重塑的理解的最新进展为研究提供了新的方向，并迫使研究人员重新评估当前公认的模型。
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