Defense of the Lungs Project, Pulmonary Disease/Critical Care, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
IEEE Trans Biomed Eng. 2010 Jul;57(7):1539-46. doi: 10.1109/TBME.2010.2041453. Epub 2010 Feb 17.
High-frequency chest compression (HFCC) can be used as a therapeutic intervention to assist in the transport and clearance of mucus and enhance water secretion for cystic fibrosis patients. An HFCC pump-vest and half chest-lung simulation, with 23 lung generations, has been developed using inertance, compliance, viscous friction relationships, and Newton's second law. The simulation has proven to be useful in studying the effects of parameter variations and nonlinear effects on HFCC system performance and pulmonary system response. The simulation also reveals HFCC waveform structure and intensity changes in various segments of the pulmonary system. The HFCC system simulation results agree with measurements, indicating that the HFCC energy transport mechanism involves a mechanically induced pulsation or vibration waveform with average velocities in the lung that are dependent upon small air displacements over large areas associated with the vest-chest interface. In combination with information from lung physiology, autopsies and a variety of other lung modeling efforts, the results of the simulation can reveal a number of therapeutic implications.
高频胸壁压缩（HFCC）可作为一种治疗干预手段，用于协助囊性纤维化患者的黏液转运和清除，并增强水分泌。使用惯性、顺应性、粘性摩擦关系和牛顿第二定律，开发了一种带有 23 个肺代的 HFCC 泵背心和半胸肺模拟装置。该模拟在研究参数变化和非线性效应对 HFCC 系统性能和肺系统响应的影响方面非常有用。该模拟还揭示了 HFCC 波形结构和在肺系统各个部分的强度变化。HFCC 系统模拟结果与测量结果一致，表明 HFCC 能量传递机制涉及机械诱导的脉动或振动波形，其平均速度取决于与背心-胸部界面相关的大面积上的小空气位移。结合肺生理学、尸检和各种其他肺建模工作的信息，模拟结果可以揭示许多治疗意义。
