Department of Dermatology and Allergy, Technische Universität München, Munich, Germany.
Eur J Dermatol. 2010 Mar-Apr;20(2):145-51. doi: 10.1684/ejd.2010.0828. Epub 2010 Feb 19.
Hair loss in elderly women has been becoming a major topic in the daily practice of dermatology. Aging of hair follicles seems to affect hair growth and pigmentation, the molecular mechanisms of which remain to be elucidated. Further senile changes in physiology and immunity may influence the onset and course of hair diseases. Some preexisting diseases such as androgenetic alopecia usually worsen after menopause, while others, like discoid lupus erythematosus, may attenuate. Hormone surveying, especially with regard to internal androgen-producing tumors, is indicated in postmenopausal women with androgenetic alopecia of sudden exacerbation or with unusual manifestation or other virilizing signs. The prevalence of alopecia totalis and alopecia universalis appears to be much lower in postmenopausal ages as compared to earlier onset. Acute or chronic telogen effluvium is not uncommonly superimposed on androgenetic alopecia. Trichotillomania shows a marked female predominance in the senile age group with a higher rate of psychopathology. Worldwide, tinea capitis has been increasingly observed in postmenopausal women. Frontal fibrosing alopecia, giant cell arteritis and erosive pustular dermatosis involve mainly elder women leading to scarring alopecia. Alopecia induced by tumor metastasis to the scalp must be considered in women with underlying neoplasms, especially breast cancer. Overall, hair loss in postmenopausal women is often multifactorial and warrants a close inspection.
老年女性的脱发问题已成为皮肤科日常实践中的一个主要议题。毛囊的衰老似乎会影响头发生长和色素沉着,但其分子机制仍有待阐明。进一步的衰老生理和免疫变化可能会影响头发疾病的发病和进程。一些先前存在的疾病,如雄激素性脱发,通常在绝经后恶化,而另一些疾病,如盘状红斑狼疮,则可能减轻。对于绝经后雄激素性脱发突然加重或表现异常或有其他男性化征象的患者,应进行激素检测,特别是针对内源性雄激素产生肿瘤的检测。与更早发病相比,绝经后全秃和普秃的患病率似乎要低得多。急性或慢性休止期脱发并不少见地叠加在雄激素性脱发上。拔毛癖在老年人群中表现出明显的女性优势,且精神病理学发病率更高。在全球范围内,绝经后妇女中头癣的发病率一直在增加。额部纤维性脱发、巨细胞动脉炎和侵蚀性脓疱性皮炎主要累及老年女性,导致瘢痕性脱发。对于有潜在肿瘤的女性,必须考虑到头皮转移瘤引起的脱发,尤其是乳腺癌。总的来说,绝经后女性的脱发往往是多因素的,需要密切检查。