Grendele M, Colledan M, Doglia M, Fassati L R, Ferla G, Gridelli B, Maggi U, Reggiani P, Rossi G, Caccamo L
Ospedale Maggiore Policlinico, Milano.
Minerva Med. 1991 Apr;82(4):151-61.
In Italy, many patients with B-virus (HBV) and Delta-virus (HDV) end-stage liver disease, are potential candidates to liver transplantation. Several authors have reported 70 to 100% hepatitis recurrence rates. From june 1983 to may 1989, 72 transplants on 60 patients were performed at Liver Transplantation Department of the Maggiore-Policlinico Hospital of Milan. The results in 26 HBsAg positive patients (19 with HDV infection), that underwent liver transplantation, are reported. A detailed report of 17 of these patients with a follow-up longer 7 months, and the clinical course of 4 patients with HBV reinfection, 3 of which had hepatitis recurrence, is also presented. The occurrence of HDV-RNA in the serum of 5 patients, that were negative for HBsAg and also other HBV-HDV replication markers after transplantation is discussed, together with the observation that in these patients no hepatitis recurrences or alteration of the clinical course were evident.
在意大利，许多患有乙型肝炎病毒（HBV）和丁型肝炎病毒（HDV）所致终末期肝病的患者是肝移植的潜在候选者。几位作者报告的肝炎复发率为70%至100%。1983年6月至1989年5月，米兰马焦雷综合医院肝脏移植科对60例患者进行了72次肝移植。本文报告了26例HBsAg阳性患者（其中19例伴有HDV感染）接受肝移植的结果。还详细报告了其中17例随访时间超过7个月的患者，以及4例HBV再感染患者的临床病程，其中3例出现肝炎复发。文中还讨论了5例患者血清中HDV-RNA的出现情况，这些患者移植后HBsAg及其他HBV-HDV复制标志物均为阴性，同时观察到这些患者无肝炎复发或临床病程改变。
