Department of Radiation Oncology, Gunma University Graduate school of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, Japan.
J Radiat Res. 2010;51(1):1-8. doi: 10.1269/jrr.09132.
Radiation therapy is one of the effective curative treatments for uterine cervical cancer. However poor clinical results for the advanced stages require further improvement of the treatment. Intensive studies on basic and clinical research have been made to improve local control, primarily important for long term survival in radiation therapy. Regarding current advancement in radiation therapy for uterine cervical cancer, the following three major subjects are pointed out; technological development to improve dose distribution by image guided radiation therapy technology, the concomitant anticancer chemotherapy with combination of radiation therapy, and radiation biological assessment of the radiation resistance of tumors. The biological factors overviewed in this article include hypoxia relating factors of HIF-1alpha, SOD, cell cycle parameters of pMI, proliferation factors of Ki67, EGFR, cerbB2, COX-2, cycle regulation proteins p53, p21, apoptosis regulation proteins Bcl2 and Bax and so on. Especially, the variety of these radiation biological factors is important for the selection of an effective treatment method for each patient to maximize the treatment benefit.
放射治疗是治疗宫颈癌的有效方法之一。然而，对于晚期宫颈癌患者，临床效果不佳，需要进一步提高治疗效果。为了提高局部控制率，基础和临床研究都在进行深入研究，这对放射治疗的长期生存至关重要。关于宫颈癌放射治疗的最新进展，主要有三个方面：通过图像引导放射治疗技术提高剂量分布的技术发展、放射治疗联合抗癌化疗以及肿瘤放射抵抗的放射生物学评估。本文综述了与肿瘤乏氧相关的缺氧诱导因子-1α（HIF-1α）、超氧化物歧化酶（SOD）、细胞周期参数 pMI、增殖因子 Ki67、表皮生长因子受体（EGFR）、CerbB2、环氧合酶-2（COX-2）、细胞周期调控蛋白 p53、p21、凋亡调控蛋白 Bcl-2 和 Bax 等生物学因素。特别是，这些放射生物学因素的变化对于为每个患者选择有效的治疗方法以最大限度地提高治疗效果非常重要。
