Sackler School of Medicine, Tel Aviv University, IL-69978 Ramat Aviv, Israel.
Neurodegener Dis. 2010;7(1-3):127-30. doi: 10.1159/000285522. Epub 2010 Feb 18.
Parkinson's disease is one of the most common neurodegenerative diseases. Although its motor symptoms are presently relatively well controlled, other manifestations are less well understood and poorly treated. Among these, the cognitive changes have a prominent role. Dementia is usually ascribed to changes in the nucleus basalis of Meynert and the cerebral cortex. This article discusses the possible contribution of vascular factors to the cognitive impairment in Parkinson's disease and its implication for the management.
帕金森病是最常见的神经退行性疾病之一。尽管其运动症状目前得到了较好的控制，但其他表现形式的了解和治疗却较差。在这些表现中，认知变化起着突出的作用。痴呆通常归因于梅内尔特基底核和大脑皮层的变化。本文讨论了血管因素对帕金森病认知障碍的可能贡献及其对治疗的影响。
