Academic Surgical Unit, University of Hull, Hull, United Kingdom.
Dis Colon Rectum. 2010 Mar;53(3):273-8. doi: 10.1007/DCR.0b013e3181ceeb22.
To assess the effectiveness of sacral nerve neurostimulation in the setting of sphincter defects, previous sphincter repair, or pudendal neuropathy.
A total of 55 patients underwent insertion of a sacral nerve neurostimulator for fecal incontinence. There were 52 female and 3 male patients, with a mean age of 51 (range, 25-65) years and a median follow-up of 37 (range, 15-41) months.
There was a significant improvement in the median Cleveland Clinic continence score for all of the patients, from a median of 15 (13-18) before insertion of the neurostimulator, to a median of between 4 and 7 during the follow-up period of up to 48 months. (P < .001-.008). Patients with a sphincter defect on endoanal ultrasound, a pudendal neuropathy, or a previous sphincter repair did not show any significant differences in continence scores during the follow-up period (P = .46, .25, and .81, respectively). The Fecal Incontinence Quality of Life score also showed a significant improvement on all 4 scales, Lifestyle (median 2.00 baseline to 3.00-3.70 P = .001-.008), Coping/Behavior (median 1.56 baseline to 2.89-3.22 P = .001-.007), Depression/Self-Perception (median 2.29 baseline to 2.93-3.71 P = .001-.005), and Embarrassment (median 1.50 baseline to 2.17-3.00 P = .001-.013) after insertion at all time intervals up to 36 months. The Fecal Incontinence Quality of Life score was higher than the baseline at 48 months but only statistically significant for Lifestyle (median 3.10, P = .04) and Coping/Behavior (median 2.63, P = .03) scores. There were 6 device-related complications.
Sacral nerve neuromodulation results in a significant improvement in fecal incontinence and Fecal Incontinence Quality of Life scores after medium-term follow-up, even when there is a sphincter defect or pudendal neuropathy.
评估骶神经神经刺激治疗肛门括约肌缺陷、先前的肛门括约肌修复或阴部神经病变患者的效果。
共有 55 名患者接受了骶神经神经刺激器的插入以治疗大便失禁。患者中有 52 名女性和 3 名男性,平均年龄为 51 岁(范围 25-65 岁),中位随访时间为 37 个月(范围 15-41 个月)。
所有患者的克利夫兰诊所失禁评分均有显著改善,从神经刺激器插入前的中位数 15(13-18)分,到随访期间中位数 4-7 分(最长随访时间 48 个月)。(P<0.001-0.008)。在超声内镜检查中存在肛门括约肌缺陷、阴部神经病变或先前的肛门括约肌修复的患者,在随访期间的失禁评分无显著差异(P=0.46、0.25 和 0.81)。粪便失禁生活质量评分在所有 4 个方面也有显著改善,生活方式(中位数基线 2.00 至 3.00-3.70,P=0.001-0.008)、应对/行为(中位数基线 1.56 至 2.89-3.22,P=0.001-0.007)、抑郁/自我认知(中位数基线 2.29 至 2.93-3.71,P=0.001-0.005)和尴尬(中位数基线 1.50 至 2.17-3.00,P=0.001-0.013)。在所有时间间隔内,从插入到 36 个月,粪便失禁生活质量评分均高于基线。在 48 个月时,除尴尬评分外(中位数 3.10,P=0.04),其他所有评分均具有统计学意义。生活方式(中位数 2.63,P=0.03)和应对/行为(中位数 2.63,P=0.03)。共有 6 例与设备相关的并发症。
即使存在肛门括约肌缺陷或阴部神经病变,骶神经神经调节在中期随访后也能显著改善粪便失禁和粪便失禁生活质量评分。