Department of Pathology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Int J Gynecol Pathol. 2010 Mar;29(2):181-4. doi: 10.1097/PGP.0b013e3181b70176.
Mucinous adenocarcinoma of the cervix has 5 subtypes: endocervical, intestinal, signet-ring cell, minimal deviation, and villoglandular. There are only rare reports of primary signet-ring cell carcinoma of the cervix in the literature. Herein we report a 53-year-old woman with cervical adenocarcinoma with signet-ring cell morphology. Thorough systemic examination did not reveal another primary focus. DNA extraction from paraffin-embedded tissue revealed the presence of human papilloma virus (HPV) type 18, which supports the cervical origin of the tumor. Signet-ring cell morphology can be observed in both benign and malignant lesions of the uterine cervix. Most of the malignant lesions are metastatic. Histological features and immunohistochemical profiles are discussed, and a review of signet-ring cell morphology in the uterine cervix is included.
宫颈黏液性腺癌有 5 种亚型：宫颈内膜型、肠型、印戒细胞型、微偏腺癌型和绒毛腺管状型。文献中仅有少数关于宫颈原发性印戒细胞癌的报道。本文报告了 1 例 53 岁宫颈腺癌伴印戒细胞形态的患者。全面系统检查未发现其他原发病灶。石蜡包埋组织的 DNA 提取显示存在人乳头瘤病毒（HPV）18 型，支持肿瘤来源于宫颈。印戒细胞形态可见于宫颈的良性和恶性病变。大多数恶性病变为转移性病变。本文讨论了组织学特征和免疫组化特征，并对宫颈印戒细胞形态进行了复习。
